Studies of pons tumor in adults

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Diffuse Intrinsic Pontine Glioma, commonly referred to as pontine glioma, infiltrative brainstem glioma, or DIPG, is a rare tumor of the brainstem that occurs almost exclusively in children. A pontine glioma occurs in a most delicate area of the brainstem the "pons"which controls many critical functions, including breathing and blood pressure. Its location, as well as the way it infiltrates normal brain tissue, makes it especially difficult to treat.

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In contrast to childhood brainstem gliomas, adult brainstem gliomas are rare and poorly understood. The charts of 48 adults suffering from brainstem glioma were reviewed in order to determine prognostic factors, evaluate the effect of treatment and propose a classification of these tumours. Mean age at onset was 34 years range 16—70 years.

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Glioblastoma multiforme malignant brain tumor cells. The cells have irregular shapes with fingers that can spread into the brain. Glioma is a type of tumor that occurs in the brain and spinal cord.

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A new type of drug that targets a genetic weakness in an untreatable childhood brain cancer could become the first ever treatment designed to target the disease. The prototype treatment could also offer hope for patients with the rare and devastating 'stone man syndrome' -- in which muscles and ligaments turn to bone. Scientists at The Institute of Cancer Research, London, led research with an international team of colleagues, finding that the new drug class can kill brain cancer cells with mutations in the ACVR1 gene and shrink tumours in mice. Open science company M4K Medicines for Kids Pharma has taken on development of the ACVR1 inhibitor drugs -- and clinical trials in children with brain cancer are expected to begin in

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Primary brain tumours are those which originate in the brain rather than having spread there from another part of the body. DIPG is a type of high grade brain tumour. High grade brain tumours tend to grow quickly and are more likely to spread to other parts of the brain or spinal cord.

Brainstem gliomas are a heterogeneous group of tumors. In contrast, tumors arising in the dorsal pons, midbrain, or medulla are usually WHO grade I pilocytic astrocytomas or ganglioglimas with a markedly better prognosis. The classic presentation is a brief less than 1 month history of cranial neuropathy, motor weakness, and incoordination.

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If we find effective ways to treat these children, the findings could apply to other difficult cancers and have a large impact on the field. Diffuse Intrinsic Pontine Glioma, often just called DIPG, is a neurologically devastating, and in most children, lethal pediatric cancer that develops in the structural tissue of the brainstem, without truly effective therapy. There are more than cases in the U.

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April 13,by NCI Staff. Two separate studies have identified potential therapeutic targets in an inoperable pediatric brain tumor, diffuse intrinsic pontine glioma DIPG. Blocking these targets with investigational drugs slowed tumor growth in animal models of DIPG.

We use cookies to give you the best possible experience. Privacy and cookies information. Pontine gliomas are malignant cancerous tumours that originate from the part of the brain known as the brain stem pons. They develop from cells called astrocytes.

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